-Forest Tennant MD PhD
As it turns out, the medications that the OIH proponents prescribe and recommend most often (serotonin increasing antidepressants, like serious SSNRIs, MAOIs, TCAs, & atypical antidepressants, like Remeron/mirtazapine) could be what is actually worsening pain in chronic pain patients! Seriously! How's that for irony? Not only are these doctors manipulating their patients out of effective treatments, but they may actually be making their pain worse with these psychotropic medications (plenty of which are neurotoxic).
* The only non-serotonin antidepressant is buproprion/Wellbutrin/Budeprion
* There is one antidepressant that actually enhanced serotonin reuptake (gets rid of the old, useless serotonin), however the FDA has not approved it (likely to avoid pissing off the multibillion dollar pro-serotonin antidepressant industry). For those of you outside the USA, the only commercially SSRE (Selective Serotonin Reuptake Enhancer) is called tianeptine/Stablon/Coaxil/Tatinol
* The National Pain Report article is based on a medical journal article in Neuron named "Central Terminal Sensitization of TRPV1 by Descending Serotonergic Facilitation Modulates Chronic Pain"
* If anyone reading this believes that they may have OIH (or knows anyone who believes that they have OIH), PLEASE email me! I'd greatly appreciate the chance to discuss it with you. If you're interested, I'll also provide you with information to help you determine if you actually have OIH.